THERAPY DOSSIER · th-6772e49ff477

Antibiotic decontamination of the gastrointestinal tract, with Pseudomonas aeruginosa contamination as a comparison condition

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01740947 ↗PHASE4terminated

Perioperative Selective Decontamination of the Digestive Tract in Elective Colorectal Cancer Patients

Colorectal Cancer

Enrolment: 485 · Results not recorded

NCT02389036 ↗PHASE3completed

Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients (SuDDICU)

Critical Illness · Sepsis · Septic Shock · Ventilator Associated Pneumonia

Enrolment: 20010 · Results not recorded

NCT05865743 ↗PHASE3recruiting

Perioperative Selective Decontamination of the Digestive Tract to Prevent Infectious Complications After Esophagectomy

Esophageal Cancer

Enrolment: 854 · Results not recorded

NCT01798537 ↗PHASE2/PHASE3unknown

Simplified Selective Digestive Tract Decontamination for Prevention of ICU Infections

Bacteremia · Ventilator Associated Pneumonia

Enrolment: 2400 · Results not recorded

NCT00250133 ↗Phase not recordedterminated

Microbiologic Effect of Selective Decontamination of the Digestive Tract With Colistin, Gentamicin and Nystatin

VRE Colonization

Enrolment: 40 · Results not recorded

NCT01535170 ↗NAunknown

Bovine Lactoferrin as a Natural Regimen of Selective Decontamination of the Digestive Tract

Nosocomial Infections

Enrolment: 280 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 3909210 ↗1985Mixed findings

Effect of Pseudomonas contamination or antibiotic decontamination of the GI tract on acute radiation lethality after neutron or gamma irradiation.

RatRadiationmaleGastrointestinal decontaminationGiven prior to irradiation

Model: Whole-body irradiation with fission neutrons (3.5 Gy and above), cyclotron-produced neutrons (4.9 Gy and above) or 137Cs gamma rays (9.6 Gy and above)

Antibiotic decontamination before irradiation increased median survival time by 1 to 5 days within the transitional dose range where death results from combined intestinal and haematopoietic injury, while Pseudomonas contamination reduced median survival time by 1 to 5 days over the same range. Nei…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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