THERAPY DOSSIER · th-64929f575fb9

Allogeneic rat bone marrow derived mesenchymal stromal cells or olfactory bulb derived olfactory ensheathing cells, a subset lentivirally transduced with GFP for tracking

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 5

4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03933072 ↗Injury indicationPHASE1/PHASE2unknown

Functional axon regeneration in complete spinal cord injury using autologous bulbar olfactory ensheathing cells and spinal cord bridging

Spinal Cord Injury at C5-Th10 Level With Complete Lesion · Spinal Cord Transection

Enrolment: 2 · Results not recorded

NCT01231893 ↗Injury indicationPHASE1unknown

Transplantation of autologous olfactory ensheathing cells for treatment of complete human spinal cord injuries: Phase I

Complete Spinal Cord Injuries

Enrolment: 10 · Results not recorded

NCT07596563 ↗Injury indicationPHASE1not yet recruiting

Safety, feasibility and efficacy of olfactory cell transplantation combined with intensive exercise rehabilitation in chronic traumatic spinal cord injury

Spinal Cord Injury · Neurological Conditions

Enrolment: 30 · Results not recorded

NCT02870426 ↗Injury indicationPhase not recordedunknown

Collection and characterisation of human olfactory ensheathing cells

Spinal Cord Injury

Enrolment: 50 · Results not recorded

NCT01327768 ↗PHASE1unknown

Safety, feasibility and treatment potential of intracerebral implantation of olfactory ensheathing cells in old stroke patients

Infarction, Middle Cerebral Artery · Ischemic Stroke · Thromboembolic Stroke

Enrolment: 6 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24146830 ↗2013Mixed findings

Gene expression changes in the injured spinal cord following transplantation of mesenchymal stem cells or olfactory ensheathing cells

RatSpinal cord injuryContusionSprague-DawleyFemale recipients; donor cells from male P22 ratsn = n = 8 per transplant group across six groups (vehicle, mese…Intraspinal intraparenchymal injection, delivered at 2 microlitres per minute through a 100 micrometre glass needle450,000 cells per rat in total; suspension at 50,000 cells…Acute transplantation 30 minutes after contusion, or delayed transplantation 7…

Model: T8 to T9 laminectomy followed by 200 kdyn spinal cord contusion using the Infinite Horizon impactor

Acute grafts of either cell type up-regulated genes linked to tissue repair including extracellular matrix organisation (Mmp13, Mmp12, Mmp9, Mmp8, Col1a1, Col1a2, Col8a1, Plod2, Lox, Postn), cell adhesion, hypoxia response and blood vessel development, with 306 genes changed at 2 days and 209 at 7…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.

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