Further Characterization of the Mitigation of Radiation Lethality by Protective Wounding.
MouseRadiationC57BL/6Female and malen = Irradiated treatment groups of 10 to 21 mice per experiment…Subcutaneous, mid-dorsal3, 6 or 12 mm subcutaneous incision approximately 1 mm deep…Within 20 minutes after irradiation; delayed incision experiments performed at…
Model: Single uniform total body exposure to 250 kVp X-rays at approximately 65 cGy/min with a 2 mm aluminium filter; doses of 6 to 7.1 Gy, with 6.8 Gy used for female mice and haematology assessed at 6.2, 6.5 and 6.7 Gy
A single subcutaneous incision made within 20 minutes of total body irradiation reduced 30-day mortality in both sexes across doses above 6 Gy, independent of incision length, and accelerated recovery of red cells, haemoglobin and platelets, but protection was lost when the incision was delayed to…
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