Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae.
MixedTBIWeight-drop / impact-accelerationC57BL/6 wild-typeMaleIntraperitoneal200 micrograms per injectionImmediately after single severe TBI in the main protocol; delayed regimens star…
Model: Closed-head weight-drop rotational acceleration injury using a 54 g metal bolt; single severe TBI at 60 inch drop height, or repetitive mild TBI at 28 inch drop height with seven injuries over nine days; anaesthesia 4% isoflurane for 45 s
Cis P-tau antibody eliminated cis P-tau induction and spread and prevented axonal pathology, tau oligomerisation and tangles, astrogliosis, TDP-43 pathology, demyelination and neuron loss, and restored sensorimotor coordination and continence after both single severe and repetitive mild TBI. No imp…
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