THERAPY DOSSIER · th-63d0e2fb9216

Bone marrow mononuclear cells, c-Kit positive cardiac mesenchymal cells (cardiac progenitor cells), freeze-thaw-killed mononuclear cells, and zymosan

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03406884 ↗PHASE1completed

Autologous Cardiac Stem Cell (c-kit+) Injection in Hypoplastic Left Heart Syndrome

Hypoplastic Left Heart Syndrome

Enrolment: 25 · Results not recorded

NCT00474461 ↗PHASE1completed

Myocardial Regeneration Using Cardiac Stem Cells From Right Atrial Appendages

Coronary Artery Disease · Congestive Heart Failure

Enrolment: 33 · Results not recorded

NCT03351400 ↗PHASE1unknown

Japanese OMI Treatment With Kit-positive Cells for Enhanced Regeneration Trial

Chronic Heart Failure · Old Myocardial Infarction

Enrolment: 6 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31775156 ↗2019Reported benefit

An acute immune response underlies the benefit of cardiac stem cell therapy.

MouseIschaemia-reperfusionCardiacC57BL/6J plus Ccr2-RFP and Cx3cr1-GFP reporter lines, Ccr2 and Cx3cr1 gene-deleted mice, mTomato reporter donors and tamoxifen-inducible c-Kit MerCreMer x Rosa26-eGFP lineage-tracing miceMale and femaleIntra-cardiac (intramyocardial) injection under isoflurane anaesthesia via left lateral thoracotomy using a 33-gauge needlePost ischaemia-reperfusion hearts: 150,000 mononuclear cell…One week after ischaemia-reperfusion injury

Model: Myocardial ischaemia-reperfusion injury by temporary left coronary artery ligation with 120 min of ischaemia before reperfusion; permanent left coronary artery occlusion used in a subset of experiments

Mononuclear cells, cardiac progenitor cells, zymosan and freeze-thaw-killed mononuclear cells each significantly improved fractional shortening and left ventricular end-systolic volume 2 weeks after injection compared with saline, with benefit persisting for at least 8 weeks for mononuclear cells a…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

Loading the evidence…