Total Coumarins from Hydrangea paniculata Show Renal Protective Effects in Lipopolysaccharide-Induced Acute Kidney Injury via Anti-inflammatory and Antioxidant Activities.
MouseEndotoxin/LPSC57BL/6Male (acute toxicity study used both sexes)n = Main study 6 groups of 8; survival study 3 groups of 9; pha…Oral gavage20 or 40 mg/kg per day; survival study 40 mg/kg; pharmacoki…Pretreatment on the two days before lipopolysaccharide, with a third dose immed…
Model: Septic acute kidney injury induced by single intraperitoneal lipopolysaccharide (Escherichia coli 0111:B4) 20 mg/kg; separate survival study used lethal lipopolysaccharide 100 mg/kg
The extract dose-dependently lowered blood urea nitrogen and neutrophil gelatinase-associated lipocalin, reduced tubular injury, oxidative stress, tubular apoptosis and leukocyte infiltration, although the improvement in survival did not reach statistical significance (p = 0.0911).
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.