THERAPY DOSSIER · th-61200eb59022

Garlic (Allium sativum) oil

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT04903808 ↗PHASE2/PHASE3unknown

Allium Sativum Oil Versus MTA in Primary Molars Pulpotomy

Carious Primary Molars

Enrolment: 26 · Results not recorded

NCT01748669 ↗PHASE2completed

Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis

Chronic Arsenic Poisoning

Enrolment: 60 · Results not recorded

NCT05801367 ↗PHASE1/PHASE2completed

Allium Sativum Oil as Alternative Non-vital Pulpotomy Medicament in Primary Teeth

Non-Vital Tooth

Enrolment: 40 · Results not recorded

NCT06755502 ↗NAnot yet recruiting

Allium Sativum (Garlic Oil) As Root Filling Material for Primary Molars

Irreversible Pulpitis

Enrolment: 40 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28530769 ↗2017Reported benefit

Beneficial effects of garlic (Allium sativum) oil in experimental corrosive esophageal burns effects of garlic oil in esophageal burns.

RatBurnChemical / corrosiven = 28 rats, randomly divided into 4 equal groups of 7Topical to the burned oesophageal segment in one group; topical plus systemic administration in a second group

Model: Corrosive oesophageal burn produced by applying sodium hydroxide to a 1.5 cm segment of the abdominal oesophagus

Hydroxyproline was lower in the topical treatment groups than in controls (p = 0.023) and tumour necrosis factor alpha differed between the systemic treatment group and control (p = 0.044). Garlic oil reduced the stenosis index, significantly so in the topical group (p = 0.016), and reduced the his…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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