Evidence & regulatory context
- Mechanism
- Not recorded
- Target
- Not recorded
- Injury models
- Burn
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Not recorded
- Note
- Not recorded
Clinical trials 6
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
A Randomized Phase III Trial of Orca-T, a T-cell-Depleted Graft With Additional Infusion of Conventional T Cells and Regulatory T Cells, vs Standard-of-Care Allogeneic Graft
Acute Myeloid Leukemia · Acute Lymphoid Leukemia · Myelodysplastic Syndrome
Enrolment: 187 · Results not recorded
Phase 1/Phase 2 Study of the Therapeutic Effect of Ex-vivo Expanded Umbilical Cord Blood Regulatory T Cells With Liraglutide on Autoimmune Diabetes
Type 1 Diabetes Mellitus · Autoimmune Diabetes
Enrolment: 40 · Results not recorded
Multiple Donor Regulatory T Cell (Treg) Infusions for Severe Refractory Chronic Graft Versus Host Disease After Allogeneic HSCT
Chronic Graft Versus Host Disease
Enrolment: 18 · Results not recorded
Safety of Donor Alloantigen Reactive Tregs to Facilitate Minimization and/or Discontinuation of Immunosuppression in Adult Liver Transplant Recipients (CTOTC-12)
Liver Transplant Recipient
Enrolment: 15 · Results not recorded
A Phase I Safety Trial of CD4+CD127lo/-CD25+ Polyclonal Treg Adoptive Immunotherapy for the Treatment of Type 1 Diabetes
Type 1 Diabetes Mellitus
Enrolment: 16 · Results not recorded
A Phase 1 Study of Single Ascending Doses of SBT777101 (Treg cell therapy) in Subjects With Rheumatoid Arthritis
Rheumatoid Arthritis
Enrolment: 48 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
MouseBurnChemical / corrosiveBALB/cMalen = Clinical evaluation combined from 3 independent experiments…Subconjunctival injection (10 microlitres at one site, 33-gauge needle)Tregs suspended in 10 microlitres of PBS per eye (the repor…Immediately after the corneal alkali burn
Model: Unilateral corneal alkali burn of the right eye: 2 mm diameter Whatman III filter paper disk presoaked for 10 s in 1 N NaOH applied to the central cornea for 40 s, followed by 1 min PBS rinsing
Subconjunctival Tregs reached the cornea within 6 h and peaked at 48 h. Treg-treated eyes showed faster epithelial closure (almost complete by 16 h versus about 25% defect remaining in controls), NEI score falling to 0 by day 13 versus a mean of 3 at day 16 in controls, faster resolution of corneal…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
