THERAPY DOSSIER · th-5c8ba0e47d6f

Neural stem/progenitor cells (tertiary neurospheres expanded with FGF-2 and EGF)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 2

2 studies reported at therapy level; 2 evidence entries itemised.

PMID 23298657 ↗2013Mixed findings

Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury.

MouseSpinal cord injuryContusionC57BL/6J host; donor neural stem/progenitor cells from ffLuc-cp156 transgenic mice on a C57BL/6J background, embryonic day 14 striataFemalen = 52 mice in total; 10 per group for the sub-acute and chroni…Intraparenchymal injection into the lesion epicentre at 1 microlitre/minCell suspension in 2 microlitres; exact cell number not rec…9 days post injury (sub-acute group) or 42 days post injury (chronic group)

Model: Contusive spinal cord injury at T10 after laminectomy using an Infinite Horizon impactor at a force-defined impact of 60 kdyn

Grafts at 9 days post injury improved BMS score, stride length, Rotarod performance, motor evoked potentials and tissue sparing, whereas identical grafts at 42 days gave no benefit despite equivalent survival and differentiation, with graft spread restricted by CS56-positive glial scar.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

PMID 23072808 ↗2012Reported benefit

Direct isolation and RNA-seq reveal environment-dependent properties of engrafted neural stem/progenitor cells.

MouseSpinal cord injuryUnspecifiedAcute transplantation after injury

Model: Spinal cord injury with acute transplantation of neural stem/progenitor cells

Acutely transplanted cells were beneficial through neuroprotection and secretion, but transcription, signalling and neural differentiation were suppressed in the injured environment.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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