In vitro Antioxidant and in vivo Wound Healing Activities of the 80% Methanol Extract and Solvent Fractions of Seeds of A. Braun (Brassicaceae) in Mice.
MixedWoundSwiss albino mice; albino rats (Rattus albus) for toxicityboth (mice of either sex); female rats for toxicityn = Six mice per group, four groups per model; toxicity study 1…Topical5% and 10% w/w ointments of crude extract and of each solve…Treatment started 24 h after wound creation
Model: Excision model: full-thickness circular dorsal excision of approximately 300 mm2 under ketamine 1 mL/kg and diazepam 1 mL/kg subcutaneously. Incision model: 3 cm linear paravertebral full-thickness incision 1 cm from the midline, closed with braided silk sutures at 1 cm intervals
The 10% w/w crude extract produced 96.6% closure at day 12, 99.1% at day 14 and 100% at day 16, comparable with nitrofurazone (92.2%, 98.4%, 100%), while 5% gave 87.6%, 96.0% and 99.5%. Epithelialisation period fell from 20 days in negative controls to 16 days (5% w/w) and 14 days (10% w/w). Tensil…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.