THERAPY DOSSIER · th-5a5c617acde5

Human induced pluripotent stem cell-derived neural progenitor cells, with tacrolimus immunosuppression

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25203632 ↗2014No effect reported

Transplanted Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Do Not Promote Functional Recovery of Pharmacologically Immunosuppressed Mice With Contusion Spinal Cord Injury.

MouseSpinal cord injuryContusionC57BL/6JFemaleIntraspinal transplantation into the contused spinal cordSubacute phase after contusion injury

Model: Contusion spinal cord injury

Human iPSC-derived neural progenitor cells transplanted into pharmacologically immunosuppressed mice showed poor long-term survival and did not improve functional recovery compared with vehicle.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

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