THERAPY DOSSIER · th-5a53cd1709cb

Hepatocyte growth factor

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound · Ischaemia-reperfusion · Burn · Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Reached clinic, not approved
ChEMBL record: CHEMBL4298081 ↗
ChEMBL max phase: Not recorded
Synonyms: Hepatocyte growth factor; Hepatopoietin-a; Recombinant human hepatocyte growth factor
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 11

11 studies reported at therapy level; 11 evidence entries itemised.

PMID 19507223 ↗2009

Regeneration of aged rat vocal folds using hepatocyte growth factor therapy

RatWound

Extraction: mesh. Machine-extracted fields require source verification.

PMID 18772314 ↗2009

IFATS collection: Fibroblast growth factor-2-induced hepatocyte growth factor secretion by adipose-derived stromal cells inhibits postinjury fibrogenesis through a c-Jun N-terminal kinase-dependent mechanism

MouseIschaemia-reperfusion

Extraction: mesh. Machine-extracted fields require source verification.

PMID 16479533 ↗2006

Attenuation of mouse acute colitis by naked hepatocyte growth factor gene transfer into the liver

Mixed

Extraction: mesh. Machine-extracted fields require source verification.

PMID missing2004

Combined administration of basic fibroblast growth factor protein and the hepatocyte growth factor gene enhances the regeneration of dermis in acute incisional wounds

Extraction: not specified. Machine-extracted fields require source verification.

PMID 12954797 ↗2003