Treatment Protocol for Extended Administration of Prometic Plasminogen (Human) by IV Infusion in Subjects With Hypoplasminogenemia
Hypoplasminogenemia
Enrolment not recorded · Results not recorded
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Biologic · Fibrinogen hydrolytic enzyme
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Hypoplasminogenemia
Enrolment not recorded · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Standardised perforation of the pars tensa in the posterior superior quadrant with a myringotomy lancet under otomicroscopy; chronic-like perforations produced by leaving plg-/- perforations untreated for 9 days
Local plasminogen restored healing in plg-/- mice dose dependently, with closure at day 9 in 10 of 10 mice at 0.4 and 0.2 mg per day, 6 of 10 at 0.1 mg per day and 0 of 10 with PBS (P<0.0001). In wild-type mice, day 7 healing was 13 of 21 with plasminogen versus 1 of 12 with PBS (P=0.0027). Subcuta…
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Model: Acute burn wound in wild-type mice and chronic diabetic wound in a mouse model of diabetes
Systemic administration of additional plasminogen accelerated healing of acute burn wounds in wild-type mice and improved healing of chronic diabetic wounds in a mouse model of diabetes, acting through potentiation of the early inflammatory response.
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