Transplantation of Skin Precursor-Derived Schwann Cells Yields Better Locomotor Outcomes and Reduces Bladder Pathology in Rats with Chronic Spinal Cord Injury.
RatSpinal cord injuryContusionSprague-DawleyFemalen = 38 rats referenced in the transplantation cohort descriptionStereotaxic intraspinal injection into the contusion siteOne million SKP-SCs in 5 microlitres of medium8 weeks post-injury
Model: Thoracic contusion spinal cord injury, treated at the chronic stage
Transplanted SKP-SCs survived to 29 weeks post-injury, integrated with host tissue, reduced dense glial scar formation, enhanced endogenous Schwann cell presence with myelination of thousands of host axons, improved locomotor outcomes and decreased pathological bladder wall thickening.
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