Changes in serum cytokine levels, hepatic and intestinal morphology in aflatoxin B1-induced injury: modulatory roles of melatonin and flavonoid-rich fractions from Chromolena odorata.
RatChemical/toxinWistar albinomale and femalen = Five groups of Wistar albino rats; numbers per group not st…oral (FCO); intraperitoneal (melatonin)FCO1 50 mg/kg and FCO2 100 mg/kg orally; melatonin 10 mg/kg…Treatment given for 7 days, with aflatoxin B1 injected on days 5 and 7
Model: Aflatoxin B1 2.5 mg/kg intraperitoneally on days 5 and 7, causing hepatic and small intestinal injury
All treatments significantly reduced serum IL-1beta, while TNF-alpha was not significantly altered. Melatonin and the higher dose of FCO gave considerable hepatic protection, but melatonin was not effective against the intestinal lesions.
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