A Phase I Single-arm Dose Escalation Study to Determine the Safety and Bioavailability of a Natural Compound Arctigenin in Healthy Men
Healthy
Enrolment: 21 · Results not recorded
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Nutraceutical
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Healthy
Enrolment: 21 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Concanavalin A (ConA)-induced acute hepatitis
Arctigenin reduced liver congestion and necroinflammation, improved hepatic ALT and AST, decreased hepatic infiltration of CD4 T cells, NKT cells and macrophages, and suppressed ConA-induced T lymphocyte proliferation, partly via enhanced IL-10 production, in a mouse model of ConA-induced acute hep…
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