Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-kappaB signal pathway.
MouseEndotoxin/LPSC57BL/65 mg/kg or 10 mg/kg in vivo; 100 micrograms/mL in RAW 264.7…Administered after lipopolysaccharide induction in vivo; in vitro cells pretrea…
Model: Acute lung injury induced with lipopolysaccharide 2.5 mg/kg
Echinacea polysaccharide reduced lipopolysaccharide-induced lung pathological damage, lung wet to dry weight ratio and myeloperoxidase activity, and lowered leukocyte, eosinophil, neutrophil, lymphocyte and macrophage counts in bronchoalveolar lavage fluid. It reduced TNF-alpha, IL-6 and IL-1beta i…
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