Acute 40% exchange-transfusion with hemoglobin-vesicles in a mouse pneumonectomy model.
MouseHaemorrhage/shockControlledC57BL/6 (specific pathogen free, inbred)Malen = n = 10 per group for survival, body weight, food intake, bl…Intravenous, via tail vein (paired with arterial withdrawal through a left carotid artery catheter)Volume equal to 40% of estimated total circulating blood vo…Exchange transfusion completed immediately before left pneumonectomy
Model: Acute isovolemic 40% exchange transfusion (estimated blood volume 56 ml/kg, six cycles of 0.1 ml withdrawal and replacement via carotid artery and tail vein) followed immediately by left pneumonectomy under mechanical ventilation
All mice given haemoglobin vesicles or mouse red blood cells survived at least 7 days after pneumonectomy, whereas all lactated Ringer's controls died within a few hours and 5 of 10 albumin-only mice died within 24 h. Haemoglobin vesicles matched red blood cells for recovery of weight, food intake…
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