THERAPY DOSSIER · th-567d000d5fd8

2-Octyl cyanoacrylate tissue adhesive

Device · Skin adhesive

Evidence & regulatory context

Mechanism: Skin adhesive
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL4297544 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: 2-octyl cyanoacrylate; Dermabond; Liquiband; Liquid bandage; Liquivet; Octylseal; Ritelok con 895
Note: Not recorded

Clinical trials 10

4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01008111 ↗Injury indicationPHASE1withdrawn

Trial title not recorded

Wound Healing

Enrolment: 0 · Results not recorded

NCT04898816 ↗Injury indicationNAcompleted

Trial title not recorded

Wound Heal

Enrolment: 20 · Results not recorded

NCT03685565 ↗Injury indicationNAcompleted

Trial title not recorded

Facial Laceration

Enrolment: 120 · Results not recorded

NCT01088074 ↗Injury indicationNAcompleted

Trial title not recorded

Total Knee Replacement Closure · Wound Closure

Enrolment: 75 · Results not recorded

NCT01110772 ↗PHASE4unknown

Trial title not recorded

Surgical Site Infection

Enrolment: 1200 · Results not recorded

NCT05508945 ↗PHASE1completed

Trial title not recorded

Surgical Incision

Enrolment: 78 · Results not recorded

NCT01794221 ↗NAcompleted

Trial title not recorded

Phimosis · Adhesions

Enrolment: 422 · Results not recorded

NCT00292513 ↗NAunknown

Trial title not recorded

Cyst of Face, Neck or Shoulder · Pilomatrixoma

Enrolment not recorded · Results not recorded

NCT06589284 ↗NAcompleted

Trial title not recorded

Arterial Catheters · Catheter Related Complication

Enrolment: 70 · Results not recorded

NCT02926521 ↗NAwithdrawn

Trial title not recorded

Regional Anesthesia Morbidity

Enrolment: 0 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32176002 ↗2020No effect reported

Histopathological Comparison of 2-Octyl Cyanoacrylate and Primary Suturing for Tongue Lacerations.

RatWoundSprague-DawleyFemalen = 24 rats, n = 6 per group across four groupsTopical application to the incision siteApplied at the time of injury

Model: Single linear incision on the midline dorsal tongue

Operative time was significantly shorter with the adhesive (p < 0.001). At day 5 moderate acute inflammatory cell infiltration and foreign body residue were more frequent with the adhesive, but by day 21 histopathology was indistinguishable from suturing (p > 0.05).

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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