Photodynamic antimicrobial chemotherapy with the novel amino acid-porphyrin conjugate 4I: In vitro and in vivo studies.
MouseWoundBALB/cFemalen = Five groups of six mice eachTopical application to the wound followed by 650 nm laser illumination50 microlitres of 40 micromolar 4I applied to the wound; in…Applied after wound infection was established
Model: Full-thickness dorsal excisional wound of approximately 1 cm by 1 cm infected with multidrug-resistant Acinetobacter baumannii, in mice immunosuppressed with intraperitoneal cyclophosphamide 150 mg/kg and 100 mg/kg on days 1 and 4 before wounding
4I-mediated photodynamic antimicrobial chemotherapy achieved more than 2.89 log reduction of multidrug-resistant Acinetobacter baumannii at 24 hours after treatment compared with untreated mice and accelerated wound recovery, whereas 4I alone or light alone had no visible antimicrobial effect.
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