THERAPY DOSSIER · th-560a56e0287b

Ononis spinosa subsp. leiosperma root ethyl acetate extract (n-hexane, ethyl acetate and methanol extracts of four Ononis taxa tested)

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 28531920 ↗2017Reported benefit

Wound healing and anti-inflammatory activity of some Ononis taxons.

MixedWoundSprague-DawleyMale

Model: Linear incision and circular excision cutaneous wound models, with carrageenan-induced hind paw oedema, TPA-induced ear oedema, FCA-induced arthritis and acetic acid-induced capillary permeability as inflammation models

Ononis spinosa subsp. leiosperma root ethyl acetate extract gave a 42.6% tensile strength value on the linear incision model and 60.1% wound area reduction at day 12 on the circular excision model, with tissue hydroxyproline of 41.3 micrograms per mg. The same extract inhibited acetic acid-induced…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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