Stem cells from foreign body granulation tissue accelerate recovery from acute kidney injury.
RatIschaemia-reperfusionRenalFischer F344MaleIntravenous3 h after injury
Model: Renal ischaemia-reperfusion acute kidney injury
A single intravenous dose of granulation tissue stem cells lowered plasma creatinine and blood urea nitrogen at 24 and 48 h with return towards baseline by day 4, increased tubular cell proliferation and reduced apoptosis, although histological injury scores did not differ between groups.
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