Pretreatment with phencyclidine, an N-methyl-D-aspartate antagonist, attenuates long-term behavioral deficits in the rat produced by traumatic brain injury.
RatTBIFluid percussionIntraperitoneal1.0, 2.0 or 4.0 mg/kgPretreatment, 15 min before injury
Model: Fluid-percussion traumatic brain injury (moderate)
PCP did not alter the duration of acute behavioural suppression. At 1.0 mg/kg it attenuated all long-term deficits except beam walking, with maximal protection against beam walking deficits at 4.0 mg/kg. Mortality within 10 days was 63% with saline versus 40%, 23% and 33% at 1.0, 2.0 and 4.0 mg/kg.…
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