THERAPY DOSSIER · th-55042c449862

Neuromuscular electrical stimulation with kilohertz-frequency alternating current (8 kHz) via percutaneous needle electrodes, compared with 75 Hz low-frequency stimulation

Device

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06964438 ↗NArecruiting

NMES With or Without Protein Supplementation to Preserve Muscle Mass After Abdominal GI Cancer Surgery

Muscle Atrophy · GI Cancer

Enrolment: 45 · Results not recorded

NCT04197791 ↗NAunknown

Core Stabilization Exercises and NMES in Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis

Enrolment: 36 · Results not recorded

NCT03788876 ↗NAunknown

Neuromuscular Electrical Stimulation After Lung Transplantation: RCT

Lung Transplantation

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 26510623 ↗2015Mixed findings

The efficacy of neuromuscular electrical stimulation with alternating currents in the kilohertz frequency to stimulate gait rhythm in rats following spinal cord injury.

RatSpinal cord injuryContusionFischer (given as strain F334 in the full text)Femalen = n=5 per group, total N=20Percutaneous needle electrodes inserted near the motor points of the tibialis anterior and gastrocnemius of both hindlimbsPulse width 40 microseconds, current amplitude set at 1.5 t…Commenced on day 7 after injury

Model: Incomplete contusive spinal cord injury at T9 produced with an Infinite Horizon impactor (IH-400) at 150 kdyn after T9 laminectomy

BBB scores at day 14 did not differ between groups (14.8 plus or minus 0.7 in both NMES groups versus 14.4 plus or minus 1.0 in untreated injured rats). On three-dimensional gait analysis the 8 kHz group differed significantly from untreated injured rats in the interlimb coordination R value (0.87…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

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