Combination treatment of podophyllotoxin and rutin promotes mouse Lgr5 intestinal stem cells survival against lethal radiation injury through Wnt signaling.
MouseRadiationC57BL/6Male
Model: Lethal whole-body ionising radiation causing gastrointestinal injury with intestinal crypt stem cell loss
G-003M improved survival and intestinal structural and functional regeneration after lethal irradiation, expanded Lgr5-positive crypt stem cells via beta-catenin nuclear translocation and reduced inflammation, with the benefit lost under Wnt inhibition by XAV939 and with a better anti-tumour respon…
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