THERAPY DOSSIER · th-519e2c22264b

Human umbilical cord mesenchymal stem cells; collagen (7% bovine collagen gel, Collost); deproteinised calf blood haemoderivative (Actovegin)

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 10

2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT02283879 ↗Injury indicationPHASE1unknown

Human Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Cerebral Hemorrhage

Cerebral Hemorrhage

Enrolment: 20 · Results not recorded

NCT06122532 ↗Injury indicationNAnot yet recruiting

Clinical Study on Umbilical Cord Mesenchymal Stem Cells for Wound Repair in Large Area Burn Patients

Large Area Burns

Enrolment: 20 · Results not recorded

NCT05631717 ↗PHASE3unknown

Comparing the Efficacy and Safety of Human Umbilical Cord Mesenchymal Stem Cells and Low-dose IL-2 in the Treatment of Lupus Nephritis

Systemic Lupus Erythematosus · Lupus Nephritis

Enrolment: 40 · Results not recorded

NCT06147986 ↗PHASE2recruiting

A Phase IIa Study to Evaluate Allogeneic Umbilical Cord Mesenchymal Stem Cells As an Add-On Treatment for Acute STEMI Patients

ST Elevation Myocardial Infarction

Enrolment: 41 · Results not recorded

NCT01494480 ↗PHASE2unknown

The Clinical Study on the Use of Umbilical Cord Mesenchymal Stem Cells in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

Enrolment: 30 · Results not recorded

NCT04314011 ↗PHASE1/PHASE2completed

A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Study of Umbilical Cord Mesenchymal Stem Cells Infusion for Aging Frailty

Aging Frailty

Enrolment: 30 · Results not recorded

NCT04992832 ↗PHASE1/PHASE2completed

Multi-intravenous Infusion of Umbilical Cord Mesenchymal Stem Cells for Treatment in Heart Failure Patients With Reduced Ejection Fraction

Heart Failure, Systolic

Enrolment: 40 · Results not recorded

NCT02834858 ↗PHASE1unknown

Umbilical Cord Mesenchymal Stem Cells Infusion for Diabetes Related Vascular Complications

Peripheral Vascular Disease · Ischemia · Diabetic Foot

Enrolment: 240 · Results not recorded

NCT05872659 ↗EARLY_PHASE1unknown

Human Umbilical Cord Mesenchymal Stem Cells Combined With Antiviral Therapy in AIDS Patients With Immune Non-responder

AIDS Virus · Disorder of Immune Reconstitution

Enrolment: 20 · Results not recorded

NCT03724617 ↗NAcompleted

Clinical Study of Stem Cells in the Treatment of Thin Endometrium (umbilical cord MSCs combined with collagen scaffold)

Thin Endometrium · Intrauterine Adhesion

Enrolment: 18 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 33209017 ↗2020Mixed findings

Comparative Analysis of the Effectiveness of Some Biological Injected Wound Healing Stimulators and Criteria for Its Evaluation.

RatWoundWistarMalen = 112 wounds, four groups of 28 wounds, seven wounds per grou…Local injection into the wound edges0.2 mL per wound in all groups (0.1 mL lateral edge and 0.1…On the day of wounding

Model: Standardised square full-thickness acute skin wound on the back created with a patented device, depth to the latissimus dorsi fascia, mean area 123 mm2

Mesenchymal stem cells gave a rapid but short-lived benefit, being the only treatment to reduce wound area significantly by day 3, while collagen gave a delayed but sustained benefit with the smallest wound areas and highest complete epithelialisation at days 7 and 14. Deproteinised calf blood haem…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

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