Drug
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Advanced Basal Cell Carcinoma (BCC) · Inoperable Disease
Enrolment: 20 · Results not recorded
Breast Cancer · Breast Surgery · Sentinel Lymph Node Biopsy · Intraoperative Hypotension
Enrolment: 220 · Results not recorded
Postoperative Delirium
Enrolment: 314 · Results not recorded
5 studies reported at therapy level; 5 evidence entries itemised.
Model: Acute lung injury induced by an oleic acid bolus
Trends favouring improved permeability (wet to dry weight ratio and protein) were not statistically significant, but histological analysis showed reduced lesion areas in both the pre-treatment and post-treatment groups. The authors concluded the benefit was apparent only on macroscopic and histolog…
Extraction: extract · Supplied extraction confidence: 0.62. Machine-extracted fields require source verification.
Model: Controlled cortical impact to the right frontoparietal cortex (3.0 m/s, 100 ms dwell, 2 mm depth, 2.5 mm tip) after 4 mm craniotomy
Methylene blue reduced injured hemisphere brain water content at 24 h, lowered modified neurological severity scores at 24 and 72 h, reduced lesion volume at all time points, preserved neurons and inhibited microglial activation at 72 h and 14 days, with increased markers of autophagy.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.
Model: Controlled cortical impact to the primary forelimb somatosensory cortex in rats
Methylene blue given 24 h after injury still reduced lesion volume and functional deficits relative to vehicle.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.
Model: Midline fluid percussion injury (diffuse brain injury); complementary in vitro experiments with lipopolysaccharide-activated BV2 microglia
Immediate intravenous methylene blue reduced cerebral oedema, attenuated microglial activation and significantly reduced hippocampal inflammatory gene expression at 1 day post injury, and attenuated TBI-induced IL-1β and TNF-α expression in enriched microglia/macrophages. In vitro, methylene blue d…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
Model: Corrosive alkali burn of the distal oesophagus with 30 per cent sodium hydroxide solution
Methylene blue raised tissue superoxide dismutase and total antioxidant status, lowered total oxidant status and significantly attenuated histopathological damage in the acute phase of corrosive oesophageal burn.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.
