Alpha-7 nicotinic acetylcholine receptor agonist treatment reduces neuroinflammation, oxidative stress, and brain injury in mice with ischemic stroke and bone fracture.
MouseIschaemia-reperfusionCerebral (MCAO/stroke)C57BL/6JMalen = 11 mice per group for behavioural tests, of which 7 were us…Injection of drug diluted in 0.9% saline; specific route not stated in the full textPHA 568487 0.8 mg/kg; methyllycaconitine 6 mg/kg (dose-find…1 and 2 days after permanent middle cerebral artery occlusion, that is at and a…
Model: Permanent middle cerebral artery occlusion by electrical coagulation proximal to the pyriform branch, followed 1 day later by open right tibia fracture with intramedullary fixation
PHA 568487 improved behavioural performance, reduced infarct volume, apoptotic neurons, CD68 cells and M1 macrophages, increased M2 macrophages and antioxidant gene expression, and reduced NF-kappaB p65 phosphorylation. Methyllycaconitine produced the opposite effects.
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