Beneficial effects of the kappa opioid receptor agonist U-50488H in experimental acute brain and spinal cord injury.
MouseTBIClosed-head / concussionCF-1 miceMale (mice)n = 4 untreated cats; mouse group sizes not statedIntravenousMice 1, 3 or 10 mg/kg for the grip test; 10 and 20 mg/kg fo…Within 3 to 5 min after concussive head injury
Model: Concussive head injury in mice (900 g/cm) and contusive spinal cord injury in cats (500 g/cm)
U-50488H produced a dose-related improvement in early neurological recovery in injured mice, significant at 3 and 10 mg/kg. It partially reversed the injury-induced fall in forebrain perfusion, significantly at 60 min after 20 mg/kg. In untreated cats spinal cord blood flow fell progressively from…
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