THERAPY DOSSIER · th-4f6a21245d17

Sevoflurane

Drug · Halogenated inhalational general anaesthetic; GABA-A/glycine receptor positive modulator.

No trauma translation Suggest a correction

This record is classified as “NO TRAUMA TRANSLATION”. Read the indication and notes below for the specific context.

Evidence & regulatory context

Mechanism: Halogenated inhalational general anaesthetic; GABA-A/glycine receptor positive modulator.
Target: CHEMBL2363052 (Glycine R); CHEMBL2093872 (GABA-A)
Injury models: TBI
Reported indication: Not recorded
First approval: 1995
Development stage: Not recorded
ChEMBL record: CHEMBL1200694 ↗
ChEMBL max phase: 4 / 4 (development scale, not regulatory approval)
Synonyms: Ultane; Sevorane; Sojourn
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03514550 ↗PHASE4completed

Immunomodulatory Effects of Sevoflurane vs TIVA in Renal Cancer

Renal Cancer

Enrolment: 20 · Results not recorded

NCT02839668 ↗PHASE2completed

IV Anaesthesia vs Sevoflurane on Angiogenesis in Breast Cancer

Breast Cancer

Enrolment: 120 · Results not recorded

NCT04725032 ↗NAunknown

TIVA vs Sevoflurane on Visual Evoked Potentials

Brain Tumor Adult

Enrolment: 84 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32091120 ↗2020No effect reported

Evaluation of Neuroprotective Effect of Sevoflurane in Acute Traumatic Brain Injury: An Experimental Study in Rats.

RatTBIUnspecifiedSprague-DawleyMalen = 30 male Sprague-Dawley rats in three groupsInhalationApplied after induced trauma

Model: Diffuse acute traumatic brain injury model

Sevoflurane administration after acute traumatic brain injury did not prevent the development of oxidative stress or inflammation. Treated animals showed degenerative neuronal and glial changes, vascular enlargement and congestion, perivascular inflammatory infiltration, and positive VEGF and TNF-a…

Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.

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