Phase III Study of Minocycline in Acute Spinal Cord Injury (includes surgical spinal cord decompression arm)
Spinal Cord Injuries
Enrolment: 248 · Results not recorded
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Procedure
4 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Spinal Cord Injuries
Enrolment: 248 · Results not recorded
Spinal Cord Injuries
Enrolment: 339 · Results not recorded
Traumatic Spinal Cord Injury
Enrolment: 100 · Results not recorded
Central Spinal Cord Syndrome
Enrolment: 1 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Clip compression injury of the spinal cord at C7-T1 at forces of 2.3, 16.9 or 53.0 g
Injury force was the major determinant of recovery: rats injured with the 2.3 g clip performed better than those injured at higher forces at all decompression times (p less than 0.0001), and the 16.9 g group outperformed the 53.0 g group at 15 minutes only (p less than 0.05). Time to decompression…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Acute clip compression spinal cord injury with independently varied compression force and duration
Earlier decompression improved functional recovery, and increasing either the force or the duration of compression reduced recovery.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.