THERAPY DOSSIER · th-4be1ad6bcc60

Acute electrical stimulation and early forced treadmill running, alone and in combination

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

3 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01236976 ↗Injury indicationPHASE3completed

SCIPA Full-On: Intensive Exercise Program After Spinal Cord Injury (Therastride Treadmill System, FES-assisted cycling)

Spinal Cord Injury

Enrolment: 116 · Results not recorded

NCT05337982 ↗Injury indicationNArecruiting

Eccentric Motor Training With Neuromodulation and Biomarkers for Rehabilitation Readiness in Subacute SCI (Downhill Eccentric Treadmill Training with Electrical Stimulation)

Spinal Cord Injuries · Healthy

Enrolment: 49 · Results not recorded

NCT02991248 ↗Injury indicationNArecruiting

Improve Dynamic Lateral Balance of Humans With SCI (robotic training, spinal cord electrical stimulation, treadmill)

Spinal Cord Injury

Enrolment: 54 · Results not recorded

NCT00011596 ↗PHASE2completed

FNS and Weight Support Treadmill Training for Gait Component Restoration

Stroke

Enrolment: 36 · Results not recorded

NCT02812472 ↗NAcompleted

Treadmill Training With Functional Electric Stimulation in Patients With Chronic Stroke

Stroke

Enrolment: 18 · Results not recorded

NCT05549141 ↗NAunknown

Cardiovascular and Metabolic Effects of Treadmill Gait Training Associated With Functional Electrical Stimulation in Individuals Post-brain Vascular Accident

Stroke

Enrolment: 28 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 23201096 ↗2012Reported benefit

Differential effects of activity dependent treatments on axonal regeneration and neuropathic pain after peripheral nerve injury.

RatOtherSprague-DawleyFemaleElectrical stimulation applied to the injured nerve and whole-body forced treadmill exerciseElectrical stimulation for 4 hours after injury; forced treadmill running for 5…

Model: Sciatic nerve section with immediate suture repair

Sciatic nerve section induced hyperalgesia in the medial plantar skin of the injured paw, which both treadmill running and electrical stimulation reduced by different routes. Electrical stimulation enhanced motor and sensory reinnervation, and combining it with treadmill running produced strong ago…

Extraction: extract · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.

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