IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury.
MouseSpinal cord injuryContusionC57Bl/6 recipients; donor bone marrow mesenchymal stem cells from male GFP transgenic C57Bl/6 micefemale recipients, male donor cellsn = Transmission electron microscopy at 28 days used 12 animals…intralesional injection directly into the injury epicentre using a Hamilton syringe and stereotaxic frame3 microlitres of cell suspension injected at 1 microlitre p…Immediately after spinal cord injury
Model: Moderate contusion spinal cord injury of approximately 70 kdyn applied with the Infinite Horizon Impactor after T10 dorsal laminectomy
BMMSC-IGF1 improved Basso Mouse Scale scores from week 2 to week 4 and normalised gait, increased donor cell survival and antioxidant gene expression, reduced MDA and nitrite and preserved myelin, whereas wild-type BMMSCs gave no significant functional gain and lesion volume did not differ between…
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