THERAPY DOSSIER · th-4b265e72daf9

Human umbilical cord blood-derived mesenchymal stem cells preconditioned by photobiomodulation with 633 nm LED light at 1 J/cm2

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 6

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT06798727 ↗PHASE2active not recruiting

Long-term Follow-up Study on Subjects Receiving SMUP-IA-01 or Active Control

Knee Osteoarthritis

Enrolment: 84 · Results not recorded

NCT02054208 ↗PHASE1/PHASE2completed

Intraventricular NEUROSTEM (hUCB-MSC) Versus Placebo Via an Ommaya Reservoir in Patients With Alzheimer's Disease

Alzheimer's Disease

Enrolment: 46 · Results not recorded

NCT02381366 ↗PHASE1/PHASE2completed

Two Dose Levels of PNEUMOSTEM (hUCB-MSC) in Premature Infants at High Risk for Bronchopulmonary Dysplasia

Bronchopulmonary Dysplasia

Enrolment: 12 · Results not recorded

NCT04037345 ↗PHASE1completed

Phase 1 Trial to Evaluate Safety and Explore Efficacy of SMUP-IA-01 (hUCB-MSC) in Patients With Knee Osteoarthritis

Knee Osteoarthritis

Enrolment: 12 · Results not recorded

NCT07212335 ↗EARLY_PHASE1recruiting

UCB-MSCs in the Treatment of Long-Term Cytopenia After CAR-T Therapy

Immune Effector Cell Associated Hematotoxicity

Enrolment: 15 · Results not recorded

NCT06078059 ↗NAcompleted

Mechanisms of Treatment Effects Using Cultured, Allogeneic UCB-MSCs in Knee Osteoarthritis

Osteoarthritis, Knee

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 30841658 ↗2019Reported benefit

Photobiomodulation Enhances the Angiogenic Effect of Mesenchymal Stem Cells to Mitigate Radiation-Induced Enteropathy.

MouseRadiationC57BL/6maleintravenous injection via the lateral tail veinCells in 200 uL per mouse; the cell number exponent was not…2 h after irradiation

Model: Single-dose irradiation of 13.5 Gy at 2 Gy/min producing radiation-induced enteropathy

Photobiomodulation-preconditioned mesenchymal stem cells preserved mucosal architecture and epithelial barrier function, reduced endothelial cell loss and increased lamina propria angiogenesis more than untreated cells.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

Loading the evidence…