THERAPY DOSSIER · th-4b09a035a435

Adipose-derived mesenchymal stromal cells

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 9

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT03925649 ↗Injury indicationPhase not recordedno longer available

Individual patient expanded access IND of autologous HB-adMSCs for spinal cord injury

Spinal Cord Injury C5-C7

Enrolment not recorded · Results not recorded

NCT03258164 ↗PHASE3completed

Fat transplantation enriched with expanded adipose-derived autologous mesenchymal stromal cells

Breast Hypoplasia and Facial Ageing

Enrolment: 32 · Results not recorded

NCT04497805 ↗PHASE2unknown

Phase 2 study of ALLO-ASC-SHEET in diabetic Wagner grade II foot ulcers

Diabetic Foot Ulcer

Enrolment: 64 · Results not recorded

NCT04055415 ↗PHASE1/PHASE2unknown

Transplantation of adipose-derived mesenchymal stem cells to treat pulmonary arterial hypertension

Pulmonary Hypertension

Enrolment: 60 · Results not recorded

NCT02805855 ↗PHASE1completed

Safety and feasibility of autologous culture-expanded adipose-derived mesenchymal stromal cells in painful knee osteoarthritis

Knee Osteoarthritis

Enrolment: 15 · Results not recorded

NCT06592703 ↗PHASE1recruiting

Allogeneic adipose tissue-derived mesenchymal stromal cells for primary progressive multiple sclerosis: Phase I

Multiple Sclerosis

Enrolment: 10 · Results not recorded

NCT02384499 ↗PHASE1completed

Treatment of faecal incontinence using allogeneic adipose-derived mesenchymal stem cells

Fecal Incontinence

Enrolment: 21 · Results not recorded

NCT06040957 ↗NArecruiting

Bone marrow vs adipose tissue as a cell source for infiltrative treatment of knee osteoarthritis

Knee Osteoarthritis

Enrolment: 204 · Results not recorded

NCT06056427 ↗Phase not recordedno longer available

Expanded access protocol of autologous HB-adMSCs for Parkinson's disease

Parkinson Disease

Enrolment not recorded · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25791071 ↗2015Reported benefit

Intravenous delivery of adipose-derived mesenchymal stromal cells attenuates acute radiation-induced lung injury in rats.

RatRadiationSprague-DawleyFemaleIntravenous (tail vein)2 h after thoracic irradiation

Model: Thoracic irradiation causing acute radiation-induced lung injury

Intravenous adipose-derived mesenchymal stromal cells attenuated acute radiation-induced lung injury, lowering pro-inflammatory cytokines and pro-fibrotic markers, raising interleukin-10 and shifting apoptotic mediators towards cell survival.

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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