THERAPY DOSSIER · th-4ad3258af509

Whole-body heat stress

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Other
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT05708976 ↗NAcompleted

HypErthermia as an Additional Treatment for the Biology and Experience of Depression: Study 2

Major Depressive Disorder · Depression

Enrolment: 30 · Results not recorded

NCT06323785 ↗NAunknown

Randomised Sham-controlled Trial of Whole-body Hyperthermia for Depression

Major Depressive Disorder

Enrolment: 30 · Results not recorded

NCT07617649 ↗NAnot yet recruiting

Laboratory Based Identification of Heat Stress Biomarkers and Effective Cooling Interventions

Hyperthermia

Enrolment: 30 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25059237 ↗2014Mixed findings

Heat stress protects against mechanical ventilation-induced diaphragmatic atrophy.

RatOtherWistarMalen = n = 38 adult male Wistar rats across four groupsWhole-body heating1 h heat stress applied 24 h before mechanical ventilation

Model: 12 h controlled mechanical ventilation causing diaphragmatic atrophy

Heat stress increased diaphragmatic HSP72 and attenuated ventilation-induced atrophy of type I, IIa and IIx fibres, but did not protect against ventilation-induced diaphragm contractile dysfunction.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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