THERAPY DOSSIER · th-498a8b6074d7

L-alanyl-L-glutamine (glutamine donor dipeptide) combined with lentivirus-mediated HIF-1alpha siRNA knockdown

Nutraceutical

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Chemical/toxin
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL3707366 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Ala-gln; Alanyl glutamine; Alanyl-glutamine dipeptide; Dipeptamin; Glutamax; L-alanyl-l-glutamine; Sustamine
Note: Not recorded

Clinical trials 7

1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01250782 ↗Injury indicationPHASE2unknown

Effectiveness of Dipeptide N(2)-L-Alanyl-L-Glutamine in Trauma ICU Patients

Trauma ICU Patients

Enrolment: 150 · Results not recorded

NCT00732849 ↗PHASE4completed

Impact of Nutritional Support (Dipeptiven) on Infectious Complications After Upper GI Surgery

Gastrointestinal Surgery

Enrolment: 600 · Results not recorded

NCT00558155 ↗PHASE4completed

Impact of Immunostimulating Nutrition (Dipeptiven, Omegaven) After Upper GI Surgery

Gastric Cancer · Pancreatic Cancer

Enrolment: 214 · Results not recorded

NCT04560309 ↗PHASE3completed

Glutamine (L-alanyl-L-glutamine) as Myocardial Protector in Elective On-Pump CABG With Low Ejection Fraction

Coronary Artery Bypass · Cardiopulmonary Bypass · Coronary Artery Disease

Enrolment: 60 · Results not recorded

NCT01832636 ↗PHASE3completed

Alanyl-Glutamine for Inflammation, Nutrition, and Enteropathy (IMAGINE)

Malnutrition · Environmental Enteropathy · Diarrhea

Enrolment: 112 · Results not recorded

NCT01701193 ↗PHASE2completed

Alanyl-Glutamine for Reduction of Post-Myomectomy Adhesions

Pelvic Adhesions

Enrolment: 47 · Results not recorded

NCT05586646 ↗NAunknown

Effect of IV Alanyl Glutamine on Healing of Pressure Ulcers in Critically Ill Patients

Pressure Ulcer

Enrolment: 200 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 31281575 ↗2019Reported benefit

Hypoxia-Inducible Factor-1Knockdown Plus Glutamine Supplementation Attenuates the Predominance of Necrosis over Apoptosis by Relieving Cellular Energy Stress in Acute Pancreatitis.

RatChemical/toxinWistarMalen = n = 10 per group across four in vivo groups; 60 male Wistar…Intravenous via the caudal vein for both the lentiviral siRNA and L-alanyl-L-glutamineL-alanyl-L-glutamine 0.4 g/kg in vivo and 2 mM in vitro; le…Lentiviral HIF-1alpha siRNA given 5 days before pancreatitis induction; L-alany…

Model: Acute pancreatitis induced by distal pancreaticobiliary duct ligation and retrograde infusion of 3.5% sodium taurocholate (0.15 mL/100 g) into the pancreaticobiliary duct; in vitro AR42J cells exposed to 500 micromolar sodium taurocholate for 12 h

HIF-1alpha knockdown reduced histological injury scores, serum amylase and C-reactive protein, TNF-alpha and IL-1beta, myeloperoxidase and lipid peroxidase, prevented intracellular calcium rise and loss of mitochondrial membrane potential, raised ATP and lowered lactate, and increased apoptosis rel…

Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.

Loading the evidence…