THERAPY DOSSIER · th-486018f262e9

Carisbamate (CRS)

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: TBI
Reported indication: Not recorded
First approval: Not recorded
Development stage: In trials, not approved
ChEMBL record: CHEMBL2087003 ↗
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Carisbamate; Carisbamato; JNJ-10234094; RWJ-333369; RWJ-333369-000; YKP-509
Note: Not recorded

Clinical trials 10

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT00697918 ↗PHASE3completed

RWJ-333369 Extension as Adjunctive Therapy in Partial Onset Seizures (Korea/Japan)

Seizures

Enrolment: 11 · Results not recorded

NCT00697762 ↗PHASE3terminated

Double-Blind RWJ-333369 Adjunctive in Partial Onset Seizures (Korea/Japan)

Seizures

Enrolment: 56 · Results not recorded

NCT00991757 ↗PHASE3completed

RWJ-333369 Adjunctive in Partial Onset Seizures: Open-Label Extension

Epilepsy · Complex Partial Seizures · Epilepsies, Partial

Enrolment: 991 · Results not recorded

NCT00744731 ↗PHASE3completed

Open Label Extension of Carisbamate Adjunctive in Partial Onset Seizures

Epilepsy, Partial, Motor · Epilepsy, Complex Partial

Enrolment: 403 · Results not recorded

NCT00524056 ↗PHASE2completed

Carisbamate in Essential Tremor (Proof of Concept)

Essential Tremor · Movement Disorders

Enrolment: 62 · Results not recorded

NCT00870454 ↗PHASE2completed

Carisbamate for Neuropathic Pain in Diabetic Peripheral Neuropathy

Diabetic Neuropathies

Enrolment: 386 · Results not recorded

NCT00501202 ↗PHASE2completed

RWJ-333369 for Neuropathic Pain in Diabetic Peripheral Neuropathy

Diabetic Neuropathy, Painful

Enrolment: 132 · Results not recorded

NCT02435381 ↗PHASE1/PHASE2completed

Carisbamate for Alcohol Dependence

Alcohol Dependence · Alcohol Abuse

Enrolment: 11 · Results not recorded

NCT04520360 ↗PHASE1completed

Bioavailability/Food Effect of Carisbamate (YKP509)

Healthy Subjects

Enrolment: 33 · Results not recorded

NCT03731715 ↗PHASE1completed

Dose Escalation of Carisbamate in Lennox-Gastaut Syndrome

Lennox Gastaut Syndrome

Enrolment: 18 · Results not recorded

Preclinical evidence 2

1 studies reported at therapy level; 2 evidence entries itemised.

PMID 21123672 ↗2010No effect reported

Antiepileptic and antiepileptogenic performance of carisbamate after head injury in the rat: blind and randomized studies.

RatTBIFluid percussionSprague-DawleyMaleProphylactic 2-week treatment from 15 min post-injury (antiepileptogenic); 1-we…

Model: Rostral parasagittal fluid percussion injury (contusive closed head injury) with post-traumatic epilepsy

Carisbamate showed no antiepileptogenic and only equivocal transient antiepileptic effects on post-traumatic epilepsy despite adequate plasma levels.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

PMID missing2007

The novel antiepileptic agent RWJ-333369-A, but not its analog RWJ-333369, reduces regional cerebral edema without affecting neurobehavioral outcome or cell death following experimental traumatic brain injury

TBI

Extraction: not specified. Machine-extracted fields require source verification.

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