Clinical-Grade Isolated Human Kidney Perivascular Stromal Cells as an Organotypic Cell Source for Kidney Regenerative Medicine
MouseChemical/toxinC57Bl/6 for the rhabdomyolysis acute kidney injury model; outbred CD1 neonates for the neonatal kidney injection experimentMalen = n = 6 per group for blood urea nitrogen and n = 4 per group…Renal subcapsular injection, or intravenous retro-orbital injection750,000 cells per injection in 25 microlitres sterile PBS f…4 hours after glycerol injection for subcapsular delivery; 4 hours and 24 hours…
Model: Glycerol-induced rhabdomyolysis acute kidney injury, intramuscular injection on day 0 of hypertonic glycerol at 8 ml/kg body weight of a 50% glycerol solution into the inferior hind limbs
Human kidney perivascular stromal cells significantly preserved renal function, measured as blood urea nitrogen at the peak of acute kidney injury, independent of the route of delivery, and integrated into the renal interstitium. Bone marrow mesenchymal stromal cells did not show comparable interst…
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