The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome.
MouseRadiationC57BL/6 wild type and Myd88-deficientMale and femalen = Approximately 8 to 10 mice per arm across 8 independent sur…Intraperitoneal injection, total volume 50 to 70 microlitres per mouse0.25 mg/kg24 hours after total body irradiation, with a separate arm dosed at 48 hours
Model: Total body gamma irradiation at 8.8 Gy or 9.2 Gy from a caesium source
A single 0.25 mg/kg dose of FSL-1 at 24 hours after 9.2 Gy gave mean 30-day survival of 80.3 per cent across 8 independent experiments versus 22.4 per cent in untreated males, was superior to CpG, flagellin and MPLA (p = 0.0005), was effective in females (88.89 versus 14.29 per cent, p = 0.002), re…
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