THERAPY DOSSIER · th-45a1aa7c56f1

Intraoperative antegrade colonic lavage (irrigation)

Procedure

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Wound
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 3

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01196494 ↗NAterminated

Intraoperative Colonic Irrigation vs. Stent Placement in Obstructive Left-Sided Colonic Cancer

Colon Neoplasm · Intestinal Obstruction

Enrolment not recorded · Results not recorded

NCT02347280 ↗NAterminated

Loop Ileostomy With Colonic Lavage for Fulminant Clostridium Difficile Colitis

Fulminant Clostridium Difficile Colitis

Enrolment: 12 · Results not recorded

NCT01441271 ↗NAterminated

Diverting Loop Ileostomy and Colonic Lavage vs Total Abdominal Colectomy for Fulminant C. difficile Colitis

Clostridium Difficile Colitis

Enrolment: 1 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 3948617 ↗1986Reported benefit

Intraoperative antegrade lavage and anastomotic healing in acute colonic obstruction.

RatWoundn = 15 patients; number of rats not statedIntraoperative intraluminal irrigationAt the time of resection and anastomosis

Model: Acute distal colonic obstruction managed by primary resection and anastomosis, with a parallel experimental rat model of anastomotic healing after acute obstruction

In 15 patients treated by primary resection and anastomosis there were two leaks (14 per cent) and operating time was prolonged. In the rat study intraoperative irrigation improved early anastomotic colonic collagen content (p less than 0.02) and proximal and distal perianastomotic collagen content…

Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.

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