The Effect of iPS-Derived Neural Progenitors Seeded on Laminin-Coated pHEMA-MOETACl Hydrogel with Dual Porosity in a Rat Model of Chronic Spinal Cord Injury.
RatSpinal cord injuryCompressionWistarMalen = 30 rats: hydrogel n=10, iPSC-NP seeded hydrogel n=11, salin…Surgical implantation into the spinal cord lesion cavity after laminectomy and glial scar resectionCells seeded on hydrogel samples of approximately 3 x 3 x 3…5 weeks after lesion induction
Model: Balloon compression spinal cord injury at Th8-9 using a 2-French Fogarty catheter balloon inflated with 15 ul for 5 min; treated in the chronic phase after MRI-guided glial scar resection
The cell-polymer construct integrated into the chronic lesion, reduced cavitation, supported progenitor survival for 28 weeks and increased host tyrosine hydroxylase-positive fibre sprouting, but produced no significant improvement in locomotor or thermal nociceptive outcomes.
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