THERAPY DOSSIER · th-43150f3beb31

Sonic hedgehog-encoding lentivirus delivered from a macroporous gelatin or poly(ethylene glycol) sponge

Other · ChEMBL not queried: lentiviral gene-delivery construct in a scaffold, no chemical entity. ClinicalTrials.gov 'sonic hedgehog' returned 5 hits, ALL REJECTED: NCT03904862 (CX-4945), NCT04023669 (prexasertib) and NCT01878617 (vismodegib) are SHH-pathway INHIBITORS in medulloblastoma, the pharmacological OPPOSITE of Shh overexpression; NCT07676721 and NCT01731262 are OBSERVATIONAL pathway studies with no intervention. No human trial delivers Shh as a therapeutic. to_trial=false by explicit decision.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: ChEMBL not queried: lentiviral gene-delivery construct in a scaffold, no chemical entity. ClinicalTrials.gov 'sonic hedgehog' returned 5 hits, ALL REJECTED: NCT03904862 (CX-4945), NCT04023669 (prexasertib) and NCT01878617 (vismodegib) are SHH-pathway INHIBITORS in medulloblastoma, the pharmacological OPPOSITE of Shh overexpression; NCT07676721 and NCT01731262 are OBSERVATIONAL pathway studies with no intervention. No human trial delivers Shh as a therapeutic. to_trial=false by explicit decision.
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25724274 ↗2015Mixed findings

Sponge-mediated lentivirus delivery to acute and chronic spinal cord injuries.

MouseSpinal cord injuryHemisection / partialC57BL/6Femalen = 4 to 5 mice per condition, with 5 per group for immunohisto…Intrathecal, by sponge implantation into the intrathecal space without entering the cordLentivirus pipetted onto the macroporous sponge immediately…Acute delivery immediately after injury, or chronic delivery 4 weeks after inju…

Model: Dorsal laminectomy at T9 to T10 with a 2.25 mm lateral hemisection and insertion of a seven-channelled microporous poly(lactide-co-glycolide) bridge

Intrathecal sponge-mediated lentivirus gave transgene expression persisting over 12 weeks without detectable cord damage, with two-week expression about three-fold higher in acutely injured than uninjured cords. Shh lentivirus placed directly above the lesion reduced Msx2 reporter activity, increas…

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.

Loading the evidence…

Sonic hedgehog-encoding lentivirus delivered from a macroporous gelatin or poly(ethylene glycol) sponge