THERAPY DOSSIER · th-42aeea6f3597

JP4-039; MCF201-89; BEB55

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 21493014 ↗2011Reported benefit

Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators.

MouseRadiationC57BL/6 NHsdFemaleintraperitonealafter total body irradiation

Model: total body irradiation (9.5 Gy)

Mitochondrion-targeted small molecules, alone or combined, decreased radiation-induced cell death and prolonged survival of irradiated mice.

Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.

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