THERAPY DOSSIER · th-416d3a184e25

Umbilical cord derived mesenchymal stem cells; ulinastatin used as an active comparator

Biologic

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Burn
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: 3 / 4 (development scale, not regulatory approval)
Synonyms: Ulinastatin; Bikunin; Miraclid; Urinary trypsin inhibitor 1; Urinastatin; Uristatin; AER-002
Note: Not recorded

Clinical trials 7

7 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01873547 ↗Injury indicationPHASE3completed

Rehabilitation therapy versus umbilical cord derived mesenchymal stem cell transplantation in chronic spinal cord injury

Spinal Cord Injury

Enrolment: 300 · Results not recorded

NCT03505034 ↗Injury indicationPHASE2unknown

Intrathecal transplantation of umbilical cord mesenchymal stem cells in late-stage chronic spinal cord injury

Spinal Cord Injuries

Enrolment: 43 · Results not recorded

NCT03521336 ↗Injury indicationPHASE2unknown

Intrathecal transplantation of umbilical cord mesenchymal stem cells in sub-acute spinal cord injury

Spinal Cord Injury

Enrolment: 84 · Results not recorded

NCT02481440 ↗Injury indicationPHASE1/PHASE2completed

Repeated subarachnoid administration of human umbilical cord mesenchymal stem cells in spinal cord injury

Spinal Cord Injuries

Enrolment: 102 · Results not recorded

NCT06981338 ↗Injury indicationPHASE1/PHASE2not yet recruiting

Intrathecal Wharton's jelly MSC plus transcutaneous spinal cord stimulation in chronic spinal cord injury

Spinal Cord Injuries · Traumatic Spinal Cord Injuries

Enrolment: 10 · Results not recorded

NCT02237547 ↗Injury indicationPHASE1/PHASE2withdrawn

Safety and feasibility of umbilical cord tissue-derived MSC and bone marrow mononuclear cells in spinal cord injury

Spinal Cord Injury

Enrolment: 0 · Results not recorded

NCT05152290 ↗Injury indicationPHASE1recruiting

Safety of cultured allogeneic adult umbilical cord derived mesenchymal stem cells (AlloRx) for spinal cord injury

Spinal Cord Injuries

Enrolment: 20 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 24043673 ↗2013Reported benefit

Umbilical cord mesenchymal stem cell transplantation ameliorates burn-induced acute kidney injury in rats.

RatBurnUnspecifiedSprague-DawleyMaleIntravenousAfter burn trauma

Model: Severe burn trauma in rats leading to acute kidney injury

Intravenous umbilical cord mesenchymal stem cells improved survival, reduced apoptosis of resident kidney cells and lessened microscopic kidney damage after severe burn.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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