ADPase CD39 Fused to Glycoprotein VI-Fc Boosts Local Antithrombotic Effects at Vascular Lesions.
MixedOtherC57BL/6J wild typeNot stated for the ferric chloride thrombosis model; male and female used for pharmacokineticsn = 21 mice in the ferric chloride model (occlusion data from 7…Intravenous, 5 mL/kg into the right tail vein3 mg/kg (10 nmol/kg) intravenously for the thrombosis model…Injected intravenously 30 minutes before carotid injury; tail incision performe…
Model: Carotid artery exteriorised and injured by topical application of filter paper saturated with 15 per cent ferric chloride for 1 minute
Intravenous GPVI-CD39 at 3 mg/kg delayed carotid occlusion after ferric chloride injury from about 480 seconds to 1083 seconds, whereas vehicle and equimolar GPVI-Fc did not. Tail bleeding time was not prolonged at any dose, and ex vivo the fusion protein inhibited collagen, ADP and plaque-induced…
Extraction: extract · Supplied extraction confidence: 0.93. Machine-extracted fields require source verification.