Polynitroxylated Pegylated Hemoglobin-A Novel, Small Volume Therapeutic for Traumatic Brain Injury Resuscitation: Comparison to Whole Blood and Dose Response Evaluation.
MouseTBIControlled cortical impactC57BL/6 (per indexing terms)2 to 100 mL/kg in the dose response experimentGiven as resuscitation after 35 min of severe haemorrhagic shock following cont…
Model: Controlled cortical impact plus severe haemorrhagic shock to a mean arterial pressure of 25 to 27 mm Hg for 35 min, under anaesthesia
PNPH gave higher mean arterial pressure, lower heart rate, higher pH, lower serum potassium and lower intracranial pressure than Lactated Ringer's solution or whole blood, and dramatically reduced fluid requirements even at 2 or 5 mL/kg. However, brain tissue oxygenation was higher with whole blood…
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