Mitigation of the hematopoietic and gastrointestinal acute radiation syndrome by octadecenyl thiophosphate, a small molecule mimic of lysophosphatidic acid.
MouseRadiationC57BL/6FemaleSubcutaneous (earlier work used oral and intraperitoneal)Therapeutic doses around 1 mg/kg; 10 mg/kg given without ob…From 24 h before to 72 h after irradiation
Model: Total-body irradiation (lethal dose; 6.4 to 8.6 Gy range used for dose modification factor analysis)
A single dose given between 12 h before and 26 h after lethal total-body irradiation reduced mortality by 50%, and dosing at 48 to 72 h after irradiation reduced mortality by at least 34%; dose modification factor was 1.2 using LD50/10.
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