THERAPY DOSSIER · th-3f469fb9769c

Indole 3-propionic acid (IPA)

Nutraceutical · Gut-microbiota-derived tryptophan catabolite; acts as an endogenous aryl hydrocarbon receptor (AHR) and pregnane X receptor (PXR) ligand and a direct hydroxyl-radical scavenger. No ChEMBL record returned under 'indole-3-propionic acid' or 'indole-3-propionate'.

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Gut-microbiota-derived tryptophan catabolite; acts as an endogenous aryl hydrocarbon receptor (AHR) and pregnane X receptor (PXR) ligand and a direct hydroxyl-radical scavenger. No ChEMBL record returned under 'indole-3-propionic acid' or 'indole-3-propionate'.
Target: Not recorded
Injury models: Radiation
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 4

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

NCT01898884 ↗PHASE1completed

Phase 1 single and multiple ascending dose study of oral VP 20629 (indole-3-propionic acid) in adults with Friedreich's ataxia

Friedreich's Ataxia

Enrolment: 46 · Results not recorded

NCT06674018 ↗NAcompleted

Indole-3-PROpionic Acid Clinical Trials - a Pilot Study (iPROACT-pilot)

Healthy

Enrolment: 79 · Results not recorded

NCT07105514 ↗NArecruiting

Indole-3-PROpionic Acid Clinical Trials - a Pilot Study Part 2 (iPROACT-pilot2)

Healthy

Enrolment: 32 · Results not recorded

NCT07318129 ↗NArecruiting

Indole-3-PROpionic Acid Clinical Trials - Multiple Sclerosis (iPROACT-MS)

Relapsing Remitting Multiple Sclerosis

Enrolment: 220 · Results not recorded

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 32434586 ↗2020Reported benefit

Gut microbiota-derived indole 3-propionic acid protects against radiation toxicity via retaining acyl-CoA-binding protein.

MouseRadiationBALB/c; C57BL/6; nude miceMale and femaleOral

Model: Total body ionising irradiation producing acute radiation syndrome with haematopoietic and gastrointestinal injury

Oral IPA attenuated radiation-induced haematopoietic and gastrointestinal injury, lowered systemic inflammation and preserved epithelial integrity without promoting tumour growth; effects attributed to PXR/ACBP signalling.

Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.

Loading the evidence…