Evidence & regulatory context
- Mechanism
- Direct low-frequency electrical stimulation of the proximal nerve stump to accelerate axonal regeneration; physical modality, no ChEMBL entity. Search returned only unrelated neurostimulation trials, so no confident trial attribution.
- Target
- Not recorded
- Injury models
- Crush
- Reported indication
- Not recorded
- First approval
- Not recorded
- Development stage
- Not recorded
- ChEMBL record
- Not recorded
- ChEMBL max phase
- Not recorded
- Synonyms
- Brief electrical stimulation; BES; Perioperative electrical stimulation
- Note
- Not recorded
Clinical trials 0
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
No linked human trial in this dataset.
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatCrushPeripheral-nerve crushSprague-DawleyDirect electrode contact with the facial nerve proximal to the crush site30 min stimulation sessionsImmediately following the crush injury
Model: Unilateral facial nerve crush injury
A single 30 min session of electrical stimulation was as effective as daily stimulation at enhancing recovery of most functional parameters after facial nerve crush.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.
